Blood Pressure Medication At Avastin

Possible serious side effects

Everyone reacts differently to Avastin^® (bevacizumab) therapy. So, it's important to know what the side effects are.Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur.Be sure to contact your health care team if there are any signs of these side effects.

Serious side effects (not common, but sometimes fatal):

A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever

A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed

This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor

What are the other possible serious side effects?

% = Percentage of patients who had this side effect in clinical studies across different cancers

Blood pressure that severely spikes or shows signs of affecting the brain. Blood pressure should be monitored every 2 to 3 weeks while on Avastin and after stopping treatment

These may include blood clots, mini-stroke, heart attack, chest pain, and your heart may become too weak to pump blood to other parts of your body (congestive heart failure). These can sometimes be fatal

These may be caused by too much protein in the urine and can sometimes be fatal

These were uncommon with the first dose (less than 3% of patients). 0.4% of patients had severe reactions. Infusion-related reactions include high blood pressure or severe high blood pressure that may lead to stroke, trouble breathing, decreased oxygen in red blood cells, a serious allergic reaction, chest pain, headache, tremors, and excessive sweating. Your doctor or nurse will monitor you for signs of infusion-related reactions

This type of passage—known as a fistula—is an irregular connection from one part of the body to another and can sometimes be fatal

Signs include headache, seizure, high blood pressure, sluggishness, confusion, and blindness

Side effects seen most often

In clinical studies across different types of cancer, some patients experienced the following side effects:

High blood pressure
Too much protein in the urine
Nosebleeds
Bleeding
Back pain
Headache
Taste change
Dry skin
Inflammation of the skin
Inflammation of the nose
Watery eyes

Avastin is not for everyone

Talk to your doctor if you are:

Avastin should not be used for 28 days before or after surgery and until surgical wounds are fully healed

Data have shown that Avastin may harm your unborn baby. Use birth control while on Avastin. If you stop Avastin, you should keep using birth control for 6 months before trying to become pregnant

Taking Avastin could cause a woman's ovaries to stop working and may impair her ability to have children

Breastfeeding while on Avastin may harm your baby, therefore, women should not breastfeed during and for 6 months after taking Avastin

For more information about your treatment or condition, talk to your doctor.